Designed Flavins for Catalysis

Tailor-Made Catalysts - New Reactivity - Selective Editing

Accepted and Published Research Activity

Molecular Editing of Flavins for Catalysis

A. Rehpenn,# A. Walter,# G. Storch, Synthesis 2021, accepted (DOI: 10.1055/a-1458-2419).

In this Short Review, we give an overview of current strategies in tailoring molecular flavins  for specific catalytic applications. We put special emphasis on linking the position of modification to changes in catalyst activity.

Synthetic C‐6 Aminoflavin Catalysts Enable Aerobic Bromination of Oxidation‐Prone Substrates

A. Walter, G. Storch, Angew. Chem. Int. Ed. 2020, 59, 2250522509.

Our first independent group's research paper describes synthetic flavin catalysts, which allow bromination of tyrosine derivatives and other oxidation-prone substrates. We use inorganic halide salt and capitalize on reactivity that is known with flavoenzymes.

Site‐Selective Nitrene Transfer to Conjugated Olefins Directed by Oxazoline Peptide Ligands

G. Storch, N. van den Heuvel, S. J. Miller, Adv. Synth. Catal. 2020, 362, 289–294.

A Fast and Reliable Screening Setup for Homogeneous Catalysis with Gaseous Reactants at Extreme Temperatures and Pressures

M. Siebert, G. Storch, O. Trapp, Org. Proc. Res. Dev. 2020, 24, 1304–1309.

Intramolecular [2+2] Photocycloaddition of Cyclic Enones: Selectivity Control by Lewis Acids and Mechanistic Implications

S. Poplata, A. Bauer, G. Storch, T. Bach, Chem. Eur. J. 2019, 25, 8135–8148.

Terahertz Spectroscopy of Tetrameric Peptides

J. Neu, E. A. Stone, J. A. Spies, G. Storch, A. S. Hatano, B. Q. Mercado, S. J. Miller, C. A. Schmuttenmaer, J. Phys. Chem. Lett. 2019, 10, 2624–2628.

Troponoid Atropisomerism: Studies on the Configurational Stability of Tropone-Amide Chiral Axes

D. R. Hirsch, A. J. Metrano, E. A. Stone, G. Storch, S. J. Miller, R. P. Murelli, Org. Lett. 2019, 21, 2412–2415.

A Stereodynamic Redox-Interconversion Network of Vicinal Tertiary and Quaternary Carbon Stereocenters in Hydroquinone-Quinone Hybrid Dihydrobenzofurans

G. Storch, B. Kim, B. Q. Mercado, S. J. Miller, Angew. Chem. Int. Ed. 2018, 57, 15107–15111.

Supramolecular chirality transfer in stereodynamic catalysts

G. Storch, O. Trapp, Chirality 2018, 30, 1150–1160.

Investigation of Strain-Promoted Azide–Alkyne Cycloadditions in Aqueous Solutions by Capillary Electrophoresis

J. Steflova, G. Storch, S. Wiesner, S. Stockinger, R. Berg, O. Trapp, J. Org. Chem. 2018, 83, 604–613.

Attracting Enantiomers: Chiral Analytes That Are Simultaneously Shift Reagents Allow Rapid Screening of Enantiomeric Ratios by NMR Spectroscopy

G. Storch, M. Haas, O. Trapp, Chem. Eur. J. 2017, 23, 2017, 5414–5418.

Stereodynamic Quinone–Hydroquinone Molecules That Enantiomerize at sp3-Carbon via Redox-Interconversion

B. Kim, G. Storch, G. Banerjee, B. Q. Mercado, J. Castillo-Lora, G. W. Brudvig, J. M. Mayer, S. J. Miller, J. Am. Chem. Soc. 2017, 139, 15239–15244.

By-design enantioselective self-amplification based on non-covalent product–catalyst interactions

G. Storch, O. Trapp, Nat. Chem. 20179, 179–187.

Temperature-Controlled Bidirectional Enantioselectivity in Asymmetric Hydrogenation Reactions Utilizing Stereodynamic Iridium Complexes

M. Siebert, G. Storch, F. Rominger, O. Trapp, Synthesis 2017, 49, 3485–3494.

A stereodynamic phosphoramidite ligand derived from 3,3′-functionalized ortho -biphenol and its rhodium(I) complexen A stereodynamic phosphoramidite ligand derived from 3,3′‐functionalized ortho‐biphenol and its rhodium(I) complex

G. Storch, L. Deberle, J.-M. Menke, F. Rominger, O. Trapp, Chirality 2016, 28, 744–748.

Rotational Barriers of Substituted BIPHEP Ligands: A Comparative Experimental and Theoretical Study

G. Storch, F. Maier, P. Wessig, O. Trapp, Eur. J. Org. Chem., 2016, 5123–5126.

Stereodynamic tetrahydrobiisoindole “NU-BIPHEP(O)”s: functionalization, rotational barriers and non-covalent interactions

G. Storch, S. Pallmann, F. Rominger, O. Trapp, Beilstein J. Org. Chem. 2016, 12, 1453–1458.

Temperature-Controlled Bidirectional Enantioselectivity in a Dynamic Catalyst for Asymmetric Hydrogenation

G. Storch, O. Trapp, Angew. Chem. Int. Ed. 2015, 54, 3580–3586.

Tautomerization-Mediated Molecular Switching Between Six- and Seven-Membered Rings Stabilized by Hydrogen Bonding

G. Storch, M. J. Spallek, F. Rominger, O. Trapp, Chem. Eur. J. 2015, 21, 8939–8945.

CuII-selective bispidine–dye conjugates

D. Brox, P. Comba, D.-P. Herten, E. Kimmle, M. Morgen, C. L. Rühl, A. Rybina, H. Stephan, G. Storch, H. Wadepohl, J. Inorg. Biochem. 2015, 148, 78–83.

5,5′-Diamino-BIPHEP ligands bearing small selector units for non-covalent binding of chiral analytes in solution

G. Storch, M. Siebert, F. Rominger, O. Trapp, Chem. Commun. 2015, 51, 15665–15668.

Skeleton Decoration of NHCs by Amino Groups and its Sequential Booster Effect on the Palladium-Catalyzed Buchwald-Hartwig Amination

Y. Zhang, V. César, G. Storch, N. Lugan, G. Lavigne, Angew. Chem. Int. Ed. 2014, 53, 6482–6486.

Synthesis of Molecular Gallium Hydrides by Means of Low-Temperature Catalytic Dehydrogenation

D. Rudolf, G. Storch, E. Kaifer, H.-J. Himmel, Eur. J. Inorg. Chem. 2012, 2368–2372.

Straightforward Synthesis of Poly(dimethylsiloxane) Phases with Immobilized (1R)-3-(Perfluoroalkanoyl)camphorate Metal Complexes and Their Application in Enantioselective Complexation Gas Chromatography

M. J. Spallek, G. Storch, O. Trapp, Eur. J. Org. Chem. 2012, 3929–3945.